Bufo Alvarius Toad (5-MEO-DMT)

Table of Contents

Table of Contents

The Bufo Alvarius toad, also known as the Colorado River toad, is a unique amphibian that has garnered significant attention due to its association with the powerful psychoactive compound called 5-MeO-DMT. Let’s dive deeper into the world of the Bufo Alvarius toad and its connection to 5-MeO-DMT, observing its history, effects, traditional use, contemporary applications, safety considerations, extraction methods, and integration practices.

What is the Bufo Alvarius Toad?

The Bufo Alvarius toad is a relatively large amphibian, measuring up to 7 inches in length. It is characterized by its stout body, warty skin, and distinctive parotoid glands located behind the eyes, which produce bufotoxins, including 5-MeO-DMT. These glands serve as a natural defense mechanism against predators. However, in the late 1960s, when Dr. Peter Furst isolated 5-methoxy-N, N-dimethyltryptamine, or 5-MeO-DMT for short from Bufo, many researchers, shamans, and psychonauts started hunting these frogs due to its profound impact on perception and spirituality.



Throughout Mesoamerican artwork, the toad has frequently been portrayed, leading some scholars to suggest that the ingestion of Bufo secretions has been known in Mesoamerica for an extended period. However, others argue that this artistic depiction lacks sufficient “ethnohistorical evidence” to support such claims.

DMT Frog


The chemical structure of 5-MeO-DMT belongs to the tryptamine class of compounds. It is structurally similar to the more well-known psychedelic compound DMT (N, N-dimethyltryptamine) but with an additional methoxy group attached to the fifth position of the molecule. This slight modification significantly alters its effects and potency.

When consumed, 5-MeO-DMT induces profound alterations in consciousness. People commonly report a rapid onset of intense and immersive experiences characterized by a sense of ego dissolution, unity with the universe, and profound interconnectedness. These effects can be overwhelming and have been described as mystical, transformative, and out worldly. The duration of the experience is relatively short compared to other psychedelics, typically lasting around 15 to 30 minutes. During this time, people may undergo profound internal exploration, encounter visual and auditory hallucinations, and experience a sense of timelessness. The effects of 5-MeO-DMT can vary widely depending on individual factors, set, and setting.

5-MeO-DMT Dosage

Traditionally, 5-MeO-DMT and its plant sources have been consumed through insufflation, commonly referred to as snorting, in mixtures known as snuffs. Here is the recommended dosage chart.


Threshold dose

3-5 mg

Low dose

5-10 mg

Average dose

8-15 mg

High dose

10-25 mg

Currently, the most commonly used method is smoking the pure substance, with dosages ranging from 6 to 20 mg.


Threshold dose

1-2 mg

Low dose

2-5 mg

Average dose

5-10 mg

High dose

10-20 mg

Intravenous administration has also been explored, with dosages falling between 0.7 and 3.1 mg. However, this is rarely used in practice.


Bufotenin is a chemical component found in the secretions and eggs of various toad species belonging to the Bufo genus. However, it is worth noting that the Colorado River toad (Incillius alvarius) is the sole species with a significant amount of bufotenin that can induce psychoactive effects. Traditional medicines, such as ch’an su (likely derived from Bufo gargarizans), have utilized extracts of toad secretion containing bufotenin and other bioactive compounds. Although this herbal remedy has been employed for centuries in China, it is often illegally imported to the USA and prepared as tea.

Bufotein Dosage

There have been conflicting reports regarding the psychoactivity and effects of bufotenin, leading to varying conclusions from different studies. As a result, the specific dosage of bufotenin and its effects remain unclear. Based on Jonathan Ott’s bioassays, the following doses of bufotenin have been suggested.


Low dose

5-20 mg

Average dose

30-60 mg

High dose

80-100 mg


Low dose

2 mg

Average dose

4-6 mg

High dose

8 mg

Traditional and Shamanic Use of Bufo Alvarius Toad

The history surrounding the recreational and spiritual use of toad venom is relatively short, although discussions about the ritualistic utilization of toads have appeared in certain anthropological literature. Toads hold significance in the iconography and mythology of Mesoamerican cultures. Among the Maya and the Olmec, toads symbolized fertility and rain, often depicted symbolically. Remains of toads have been discovered at numerous archaeological sites.

As you can see, the use of the Bufo Alvarius toad and its secretions has a long history in various indigenous cultures throughout the Americas. Shamans and medicine people have revered the toad as a sacred ally and have incorporated its ceremonial use into their spiritual practices. The toad is often regarded as a teacher and a portal to the spiritual realms.

In traditional contexts, the Bufo Alvarius toad and 5-MeO-DMT are believed to possess powerful healing properties. The toad’s secretion is seen as a potent medicine that can facilitate spiritual growth, emotional healing, and a deep connection with the divine. It is used in rituals aimed at gaining insights, resolving inner conflicts, and achieving a state of harmony and balance.

bufo alvarius toad 5-meo-dmt

What Are the Effects

When 5-MeO-DMT is smoked or vaporized, its effects manifest rapidly and are of a short duration, typically lasting less than 20 minutes. However, these effects are often unexpectedly intense and overwhelming.

Inhalation of the vapors of 5-MeO-DMT leads to a sudden and immediate onset of effects within seconds. The peak effects are reached in less than a minute and persist for approximately 5 to 15 minutes. Users commonly describe the intensity of the experience during the appearance and plateau of effects. The effects dissipate rapidly within 5 to 15 minutes, although residual effects may be felt for up to an hour after smoking the substance.

The experience with Bufo Alvarius Toad venom is known for its immersive nature and profound alteration of perception. Many individuals report sensations of cosmic unity, accessing states of non-dual consciousness, and deep spiritual experiences. Some people experience a complete dissolution of the ego and loss of personal identity while at the same time merging with the surrounding environment. Given the rapid and intense onset of effects, feelings of fear and panic can arise, making the experience overwhelming and potentially traumatic for some individuals.

When administered via insufflation (snorting), the effects of 5-MeO-DMT tend to unfold more gradually and with less overwhelming intensity compared to smoking. However, they can still be equally powerful. The prominent effects typically last between 30 minutes to one hour, with residual effects lasting up to three hours. While the venom of Bufo Alvarius Toad is not commonly used through insufflation due to its consistency, the snorting of pure 5-MeO-DMT is relatively more prevalent.

Dangers of Bufo Alvarius Toad

Bufotenin could be dangerous, but it’s hard to say for sure because there aren’t many cases that have been thoroughly recorded. However, there have been reported instances of death linked to the consumption of bufotenin-containing toads or the use of improperly purified extracts. It’s important to note that when consuming bufotenin-containing toads for their psychoactive properties, there is a risk of ingesting other toxins present in the animal.

There are no known interactions between bufotenin and medications or other substances of abuse. However, since bufotenin shares similarities with DMT, thus there is a possibility of interactions with serotonergic antidepressants like Prozac and other SSRIs. Also possible are interactions with other serotonergic drugs, stimulant medicines, or MAO inhibitors.

Side Effects

The primary side effect commonly associated with the consumption of bufotenin-containing animals is a headache, which can persist for a few hours up to a week after ingestion. Some individuals have reported feeling nauseous and disoriented shortly after consuming these animals. Nausea, vomiting, and diarrhea are also potential side effects of consuming bufotenin-containing animals. There have been instances when long-term exposure to high levels of bufotenin caused severe psychological distress in addition to respiratory failure and even death.

The side effects of this medication may include:

  • Blisters in the mouth

  • Increased heart rate

  • Vomiting

  • Diarrhea

  • Hallucinations

Final Word

The Bufo Alvarius toad and its connection to the psychoactive compound 5-MeO-DMT offer a fascinating exploration into the realms of perception, spirituality, and personal transformation.
The active compound, 5-MeO-DMT is structurally related to DMT but with distinct effects, induces profound alterations in consciousness. Its consumption leads to intense and immersive experiences characterized by ego dissolution, unity with the universe, and a sense of profound interconnectedness. However, the effects can be overwhelming and transformative, necessitating caution and a proper set and setting.

The traditional use of the Bufo Alvarius toad and its secretions in indigenous cultures underscores its significance as a sacred ally and a gateway to the spiritual realms. It has long been revered for its potential as a tool for healing, personal growth, and the attainment of harmony and balance. While the Bufo Alvarius toad and its secretions hold immense promise, it is essential to acknowledge the associated risks and safety considerations. The potential dangers and adverse effects, including the ingestion of other toxins or interactions with certain medications, highlight the importance of informed decision-making and responsible use.

In delving into the world of the Bufo Alvarius toad and its connection to 5-MeO-DMT, we embark on a journey of exploration, self-discovery, and expanded consciousness. It is a realm that beckons with profound insights and transformative experiences, but one that also demands our utmost respect, caution, and reverence. As we navigate this intricate tapestry of natural wonders, let us approach it with humility, curiosity, and a deep appreciation for the mysteries it holds.

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