Bufo Alvarius Toad (5-MEO-DMT)

Derived from toad venom in the Sonoran Desert, or the Creosote Bush.

The Bufo Alvarius toad, also known as the Colorado River toad or Sonoran Desert toad, is a species of toad native to the southwestern United States and northern Mexico. It holds a significant place in various cultural and scientific contexts due to its unique properties and effects. Let’s explore the key features that make this toad remarkable.

Venomous Secretions

One of the most distinctive aspects of the Bufo Alvarius toad is its venomous secretions. The toad possesses specialized glands, particularly located behind its eyes, which produce a potent venom. This venom contains various compounds that can induce profound effects when consumed or applied.

Psychoactive Compounds

The venom of the Bufo Alvarius toad contains a powerful psychoactive substance called 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine). This compound is a naturally occurring hallucinogen known for its intense and transformative properties. When administered, it can produce a highly altered state of consciousness, often described as mystical or spiritual.


The Bufo Alvarius toad and its psychoactive properties have been known and utilized by indigenous cultures for centuries. Indigenous groups in the regions where the toad is found have incorporated its use in various spiritual and healing practices. It has been revered as a sacred ally for accessing higher realms of consciousness and facilitating profound spiritual experiences.

Therapeutic Potential

In recent years, the therapeutic potential of 5-MeO-DMT derived from the Bufo Alvarius toad has gained attention within the field of psychotherapy. Some researchers and practitioners suggest that guided and responsible use of this compound may have therapeutic benefits, including the treatment of mental health conditions and facilitating personal growth and transformation.

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5-MeO-DMT is a psychedelic drug with a relatively short duration of action. When smoked, the “trip” typically lasts less than 30 minutes, while insufflation can extend the experience up to 45 minutes. When vaporized and inhaled, the effects manifest almost instantly. Therefore, it is crucial to be in a safe and comfortable environment to minimize the risk of accidents.

Users frequently describe overwhelmingly intense experiences that may be challenging to recall fully. Accounts often include reports of mystical union, feelings of non-duality, and transpersonal encounters. It is not uncommon to experience uncomfortable bodily sensations such as a rapid heart rate, nausea, or pressure in the chest.The perceptual alterations induced by 5-MeO-DMT encompass various sensory realms, including auditory and visual hallucinations, internal scenes, distortions of time perception, and shifts in cognition and emotion. Some users note that 5-MeO-DMT produces less visual intensity compared to NN-DMT.As with other psychedelic substances like psilocybin and LSD, the range of experiences with 5-MeO-DMT can span from euphoric and spiritually significant to dysphoric and potentially psychologically distressing. Individual responses and reactions can vary greatly.It is important to approach the use of 5-MeO-DMT with caution, respect, and a comprehensive understanding of the potential risks and benefits. Seeking guidance from experienced practitioners, ensuring proper set and setting, and adhering to legal and ethical considerations are vital for promoting a safe and meaningful experience.


Ego-Dissolution and Connectedness​

One of the most notable effects of 5MeO-DMT and Bufotenine is the profound dissolution of the ego, which can lead to a sense of interconnectedness with all existence. This ego-dissolution experience can be enlightening, allowing individuals to transcend their ordinary sense of self and experience a profound connection with the universe. This dissolution of the ego can help individuals gain insights into the nature of reality and their place within it, fostering feelings of unity, compassion, and empathy.

Spiritual Awakening and Transcendence​

Entheogenic experiences with 5MeO-DMT and Bufotenine have been described as catalysts for spiritual awakening. The profound nature of these journeys often leads individuals to transcend ordinary perceptions of reality, offering glimpses into expanded states of consciousness. This transcendence can foster a deeper connection with one’s spiritual self, open doors to mystical experiences, and promote a broader understanding of the nature of existence. Such encounters can be deeply transformative, leaving individuals with a renewed sense of spirituality, purpose, and interconnectedness.


The benefits of MeO-DMT and Bufotenine extend beyond the immediate experience, with many individuals reporting a prolonged “afterglow” that can last for hours, days, or even weeks. This afterglow is characterized by a sense of clarity, enhanced well-being, and integration of the insights gained during the entheogenic journey. Participants often describe a heightened appreciation for life, increased mindfulness, and a shift in perspective, enabling them to make positive changes in their lives and relationships.

Setting Intention and Ceremony

To optimize the benefits of MeO-DMT and Bufotenine, participants are encouraged to set intentions before the ceremony. By clarifying their goals and desires, individuals can focus their attention on specific areas of personal growth, healing, or spiritual exploration. The ceremonial setting provides a safe and supportive environment for the entheogenic experience, with experienced guides available to offer guidance and assistance throughout the journey. This intentional approach enhances the potential therapeutic and transformative effects of these entheogens.


To prepare for a Bufo ceremony, follow the provided instructions, including dietary restrictions and minimizing distractions. Set a clear intention and surrender to the experience. Aligning with the guidelines maximizes the benefits of this powerful medicine.

In summary, for a Bufo ceremony, it is advisable to adhere to the provided preparation instructions, which may include dietary restrictions and minimizing external distractions. Setting a clear intention and surrendering to the experience will help create a receptive and transformative space for the medicine to work its profound effects.


Integration is crucial after any entheogenic experience, including a Bufo ceremony. Take time in the days following the ceremony to be in a quiet space for reflection and processing of thoughts. Utilize meditation and calming music as tools to connect with your inner self and integrate the insights gained from the journey. These practices will guide you in tuning into your newfound self and nurturing personal growth.
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Bufo Alvarius, commonly found in the Sonoran Desert, holds a historical significance in ancient rituals, and its potent effects have been recognized by anthropologists. The dried venom, typically smoked through a pipe or vape, offers an experience lasting around 15 to 30 minutes. Scientists have measured its potency to be approximately five times stronger than synthetic DMT. Consult our guides to explore whether Bufo Alvarius could be a suitable option for your journey.

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Bufo Alvarius toad venom is typically dried and then smoked, vaporized, or insufflated (snorted).

The effects of 5MeO-DMT include intense spiritual experiences, hallucinations, and altered states of consciousness, potentially leading to therapeutic and transformational growth.

As smoking is the most common route of administration for 5-MeO-DMT, individuals with lung conditions such as asthma are at a higher risk of experiencing adverse effects. Moreover, due to its potential to increase heart rate, individuals with cardiac problems should avoid Bufo. It is important to note that individuals predisposed to or already experiencing schizophrenia or psychosis may encounter the onset or exacerbation of symptoms with the use of 5-MeO-DMT.

Based on a 2018 study conducted on 5-MeO-DMT users, it was concluded that the substance is primarily used infrequently and predominantly for spiritual exploration rather than recreational purposes. The study found that 82% of the participants reported using 5-MeO-DMT for spiritual or healing/psychological reasons, indicating its non-recreational nature. For this reason, it's highly unlikely that you will get addicted to Bufo.

The best practice is to seek guidance from experienced practitioners, carefully consider set and setting, and adhere to responsible use. If you are not sure where to find reputable Bufo practitioners, visit our Plant Medicine Directory.

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